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While suicidal ideation is certainly an important consideration with overdose, this case illustrates the abuse potential of prescription drugs not generally thought of as dugs of abuse. Bupropion in particular possess dopaminergic and noradrenergic activity making it an attractive choice for those seeking a cocaine like high.

Bupropion is both cheaper and easier to obtain than illicit substances like amphetamines and cocaine, and should be on our radar as a potential drug of abuse. Handbook of Experimental Pharmacology. Bupropion Overdose: Significant Toxicity in Pediatrics.

Clin Pediatric Emerg Medicine. Pediatr Neurol. Sustained release bupropion overdose: an important cause of prolonged symptoms after an overdose. Emerg Med J. Seizures after bupropion overdose.

Storrow AB. Bupropion overdose and seizure. Am J Emerg Medicine. Intentional bupropion overdoses. J Emerg Medicine. A center prospective study of seizure in association with bupropion. J Clin Psychiatry. A prospective safety surveillance study for bupropion sustained-release in the treatment of depression. Evolving epidemiology of drug-induced seizures reported to a poison control center system.

J Medical Toxicol. Miller L, Griffith J. A comparison of bupropion, dextroamphetamine, and placebo in mixed-substance abusers. A comparison of bupropion hydrochloride with dexamphetamine and amitriptyline in healthy subjects. Brit J Clin Pharmaco. Welsh CJ, Doyon S. Seizure Induced by Insufflation of Bupropion. New Engl J Medicine. McCormick J. Recreational bupropion abuse in a teenager.

Paggio D. Measurements and main results: Cases in the surveillance database were evaluated based on documented doses, treatment sites, symptoms, and clinical outcomes by using standard data-field definitions.

Over a 4-year period from , more women than men unintentionally took extra doses of bupropion [ Ingested doses ranged from mg with a median and mode of mg. Of the patients, only Seizures were reported in four patients 0. Background: Delayed seizures have been reported with overdoses of bupropion extended-release XL.

This study systematically evaluates the frequency and timing of seizures and an association between other toxic effects ie, agitation, tremors, and hallucinations and seizures. Patients with coingestants or a medical history that could affect seizure occurrence were excluded.

Data collection forms captured onset time of seizure s , other symptoms, and treatment.